Begin your Beaune exploration at the spectacular Hôtel-Dieu (Hospices de Beaune) with its iconic multi-colored glazed tile roof in geometric patterns and stunning Gothic architecture that has welcomed visitors for over 550 years. Tour this 15th-century charity hospital turned museum to see the famous polyptych altarpiece by Flemish master Rogier van der Weyden depicting the Last Judgment in extraordinary detail, and explore the Grande Salle with its original carved wooden ceiling and period furnishings. Descend into the ancient wine cellars beneath the city for guided tastings of prestigious Burgundy wines in atmospheric stone-vaulted caves that maintain perfect temperature and humidity year-round. Walk the medieval ramparts that still encircle the old town and explore the charming cobblestone streets with their wine shops, art galleries, and traditional restaurants serving regional specialties. Visit the Marché aux Vins in a former 15th-century church for comprehensive tastings of Côte d'Or wines, or book guided tours of prestigious wineries in the surrounding Golden Slope vineyards including Pommard, Volnay, and Meursault. Sample classic Burgundian cuisine like coq au vin made with local Pinot Noir, boeuf bourguignon slow-cooked in red wine, and creamy époisses cheese paired with the region's legendary wines that express the unique terroir of these ancient vineyard slopes.